Genetic code, which is on 4 kinds of DNA, is passed down from ancestors to all living things. DNA is similar to Inosinic acid, an “umami” component in bonito juice. However, DNA composition can be changed due to various physical factors, resulting in mutations that can cause diseases like cancer and senescence. Therefore, the anti-mutagenic effect is significant for humans.
Green Tea Catechins and Their Anti-mutagenic Effect
Dr. Tsuneo Kada discovered 20 years ago that tea leaves extract and EGCG in catechins have an anti-mutagenic effect, making Japan a leader in the field of mutation research. Green tea catechins have three ways to control mutation. Firstly, Toripu‐Ｐ‐２ and Jinitropiren react directly to suppress the reaction of DNA and mutant. Secondly, green tea catechins derive detoxification, which promotes an anti-tumor effect. Thirdly, when ultraviolet radiation causes DNA damage, catechins activate the restoration process of living things to control mutation and promote anti-tumor effects. In addition, green tea catechins react with nutric acids to control reactions with second rated amino acids when N-nitroamin is generated.
Vitamin C and Green Tea Catechins
Green tea also contains vitamin C, which has similar anti-mutagenic effects and controls the generation of carcinogens such as Nitrosoamin. Green tea catechins reduce mutation by controlling the generation of 8-OhdG produced by oxidation of DNA due to their strong anti-oxidation and free radical effects.
Timing and Amount of Drinking Green Tea
To maximize the effects of green tea catechins, timing and amount are crucial. People in Shizuoka prefecture drink tea before, during, and after meals, which has been reported to be very effective.